Pre-surgery treatment for advanced thyroid cancer
Part of Cancer, Hormones & metabolism clinical trials.
This study tests whether giving treatment before surgery (neoadjuvant therapy) helps people with locally advanced thyroid cancer. It aims to shrink the tumor so surgery can be more successful.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 14 years old or older.
- Your thyroid cancer must be locally advanced (stage T4), which means it has grown beyond the thyroid into nearby tissues.
- You must have a type of thyroid cancer that can be confirmed by a biopsy— this includes common types (differentiated, medullary, poorly differentiated, and anaplastic).
- You cannot have had any prior thyroid or major neck surgery, nor any other cancer treatments (like chemo, radiation, or targeted therapy) that could affect this plan.
- You should be able to have a tumor sample taken (biopsy) and be willing to have surgery as part of this trial.
- You must be generally healthy enough for treatment, with good organ function and no other active cancers or uncontrolled illnesses.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving targeted drugs before surgery can shrink advanced thyroid cancers that are hard to remove. It uses genetic test results to match you to a specific treatment arm, aiming to make surgery safer and more successful.
This trial tests a combination of two drugs—donafenib (a targeted therapy) and an immunotherapy (anti-PD-1 antibody)—given before surgery for locally advanced differentiated thyroid cancer. The goal is to shrink the tumor to make surgery easier and more complete. If you have this type of thyroid cancer that is hard to remove completely with surgery alone, this study may be an option.
This trial tests a targeted drug (a RET inhibitor) taken before surgery to help shrink thyroid cancer that has a specific genetic change (RET alteration). It may make surgery easier or more successful.
This trial tests a drug called zanzalintinib for people with advanced thyroid cancer that has spread nearby. The goal is to see if taking this pill before surgery can shrink the tumor and make it easier to remove.
This study looks at whether adding radiation therapy after surgery can help people with thyroid cancer that is at high risk of coming back. It includes different types of thyroid cancer, like differentiated and medullary types.
This study looks at how different genetic types of advanced thyroid cancer respond to treatment in real-world settings. It may help doctors choose the best therapy for you based on your tumor’s genetic makeup.
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