Clinical trials
Thyroid Cancer clinical trials
Below are recruiting thyroid cancer clinical trials, each written for real people, not researchers. We’re tracking 176 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07777536RecruitingPhase 2
Radiation for anaplastic and poorly differentiated thyroid cancer
This study is comparing two different ways of giving radiation therapy for anaplastic and poorly differentiated thyroid cancer. The goal is to see which method is more effective in treating the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06458036RecruitingPhase 2
Selpercatinib before radioactive iodine for RET-positive thyroid cancer
This study tests whether a targeted drug called selpercatinib, taken before radioactive iodine therapy, can help treat thyroid cancer in children and young adults who have a specific genetic change (RET fusion or mutation). The drug may make the cancer more sensitive to the radioactive iodine treatment that follows.
San Francisco, CaliforniaAges 2–25 - NCT07124000Recruiting
T-DXd for advanced HER2-positive solid tumors
This trial is for people with advanced HER2-positive solid tumors (cancers that cannot be removed by surgery or have spread). It tests the drug T-DXd (also called Enhertu) when your doctor has already decided it's the right treatment for you and you have no other good options.
Birmingham, AlabamaAges 18–130 - NCT03099356RecruitingPhase 2
Cyclophosphamide and sirolimus for thyroid cancer that won’t respond to iodine
This trial tests whether the combination of cyclophosphamide and sirolimus can slow or shrink metastatic thyroid cancer that does not respond to iodine-131. It may help people whose cancer can’t be cured with surgery or other standard options and is still growing.
Ann Arbor, MichiganAges 18 years+ - NCT03676348Recruiting
Quality of life study around thyroid surgery
This study looks at how thyroid cancer—or thyroid tumors that may be cancer—affect your quality of life before and after surgery. It may help doctors understand what patients experience and how treatment planning could be better.
OsloAges 18 years+ - NCT03765333Recruiting
Registering people with thyroid cancer for a study
This study is a registry that collects information about adults with certain types of thyroid cancer. It may help researchers learn more about these cancers and how people are doing over time.
BarcelonaAges 18 years+ - NCT03841617RecruitingPhase 2
Measure radiation in thyroid cancer using a special PET-CT scan
This trial tests how much radiation a specialized whole-body PET/CT scan delivers in patients with differentiated thyroid cancer. It may help doctors better plan treatment for cancer that persists, returns, or has spread—especially when radioactive iodine (RAI) may or may not work.
Bethesda, MarylandAges 18–90 - NCT04742608Recruiting
Liquid blood tests to diagnose thyroid nodules or cancer
This study tests whether a blood “liquid biopsy” can help diagnose thyroid cancer or hard-to-tell thyroid nodules without needing extra procedures. It may help confirm what’s going on before or around planned thyroid surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT04916990Recruiting
Care program for rural adults with several lung and head cancers
This study looks at how to improve care for adults with certain cancers who live in rural areas and may face access problems. It mainly focuses on people receiving cancer treatment at specific Colorado-area hospitals, and who are uninsured or underinsured.
Aurora, ColoradoAges 18–99 - NCT05024929Recruiting
Test targeted drugs to help radioactive iodine reach thyroid cancer
This study looks at whether certain cancer “targeted therapy” medicines can make radioactive iodine (RAI) therapy work better for thyroid cancer that has spread to the lungs. It also involves taking special whole-body scans to measure how much radioactive iodine gets taken up by the cancer.
San Francisco, CaliforniaAges birth+ - NCT05172921Recruiting
Study of environmental factors in thyroid cancer risk
This study looks at how environmental exposures may relate to thyroid cancer. If you have a suspicious thyroid nodule and are planning surgery, your biopsy or surgical tissue may be used to understand risk factors.
New York, New YorkAges 18 years+ - NCT05510934Recruiting
Thyroid cancer follow-up reminders for low-risk patients
This study tests a smartphone-based reminder system to help people with earlier-stage differentiated thyroid cancer stay on track for follow-up visits and testing. It may help catch problems sooner and make follow-up easier to manage.
Halifax, Nova ScotiaAges 18 years+ - NCT05668962RecruitingPhase 2
Study selpercatinib plus I-131 for RET thyroid cancer that cannot take iodine
This trial tests whether combining a targeted pill (selpercatinib) with a radioactive iodine dose (I-131) can shrink thyroid cancer that has spread and no longer responds to radioactive iodine. It is for RET fusion–positive (genetically driven) thyroid cancers where the cancer cannot reliably absorb iodine anymore.
Washington D.C., District of ColumbiaAges 12 years+ - NCT05733013Recruiting
Using redifferentiation medicines before radioactive iodine for thyroid cancer
This study collects information on how redifferentiation medicines used before radioactive iodine work in everyday care for certain thyroid cancers that are unlikely to respond to radioactive iodine. It may help doctors understand the best real-world way to use these medicines to plan and deliver treatment.
New York, New YorkAges 18 years+ - NCT05752604Recruiting
Study of treatments and factors in thyroid cancer
This study looks at thyroid cancer and how standard treatments and other health details relate to outcomes. You might be eligible if you have thyroid cancer and can participate by giving informed consent.
MilanAges Any age - NCT05783323RecruitingPhase 2
Larotrectinib plus radiation for thyroid cancer with NTRK fusion
This Phase 2 trial tests larotrectinib (a targeted medicine) to help radioactive iodine (RAI) work better in people with differentiated thyroid cancer that has an NTRK gene fusion. It may improve how much thyroid cancer the RAI can reach and shrink.
San Francisco, CaliforniaAges 2–99 - NCT05837260Recruiting
Tracking tumor DNA changes in advanced thyroid cancers
This study looks at a small blood test (called ctDNA) and tumor tissue to understand how advanced thyroid cancers change over time. It may help doctors better monitor cancer growth and guide treatment choices.
LondonAges 18 years+ - NCT06007924RecruitingPhase 2
Study of avutometinib and defactinib for thyroid cancer
This trial tests two oral drugs (avutometinib and defactinib) for people with certain types of advanced thyroid cancer that have specific genetic changes. The goal is to see if this combination can shrink tumors or slow their growth.
Basking Ridge, New JerseyAges 18 years+ - NCT06082180RecruitingPhase 3
Preventive neck lymph node removal in low-risk thyroid cancer
This trial is for people with low-risk papillary thyroid cancer. It compares two surgical approaches: one that removes just the thyroid gland, and another that also removes some lymph nodes in the center of the neck as a preventive measure. The goal is to see if removing these lymph nodes helps prevent the cancer from coming back.
Beijing, Beijing MunicipalityAges 18–70 - NCT06149637Recruiting
Lateral neck lymph node surgery for thyroid cancer
This trial tests a surgical procedure to remove cancer-affected lymph nodes on the side of the neck in patients with differentiated thyroid cancer. It aims to improve outcomes for those with confirmed or suspected spread to these nodes.
Medellín, AntioquiaAges 18–99 - NCT06235216RecruitingPhase 2
Sacituzumab govitecan for advanced thyroid cancer
This trial tests a new drug called sacituzumab govitecan for people with advanced thyroid cancer that has stopped responding to standard treatments. It may be an option for those with differentiated thyroid cancer (after certain prior therapies) or anaplastic thyroid cancer (first-line or after one prior treatment).
BarcelonaAges 18 years+ - NCT06236373Recruiting
Understanding cancer survivors' needs in Reggio Emilia
This study aims to understand the challenges and needs of people who have survived certain cancers (breast, prostate, thyroid, colorectal, multiple myeloma, or lymphoma) and their caregivers. It uses interviews or focus groups to gather perspectives.
Reggio Emilia, Reggio EmiliaAges 18 years+ - NCT06239194RecruitingPhase 1/Phase 2
MdX2001 for advanced solid tumors
This trial tests a new drug, MDX2001, for people with advanced solid tumors that have spread. The study aims to find the best dose and see how well it works.
Denver, ColoradoAges 18 years+ - NCT06254859Recruiting
Nerve monitoring during thyroid surgery and voice outcomes
This study tests whether using nerve monitoring during thyroid surgery helps protect the nerves that control your voice. It includes adults having one side of their thyroid removed and tracks voice changes before and after surgery.
Fuzhou, FujianAges Any age
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Thyroid Cancer trials by city
Studies with a site in or near these metro areas.
Thyroid Cancer trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for thyroid cancer?
- Yes. Clin2 currently lists 176 recruiting thyroid cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a thyroid cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a thyroid cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.