Pacing study after aortic valve replacement
Part of Heart & circulation clinical trials.
This trial tests if special pacing of the heart's lower chambers (called cardiac resynchronization therapy, or CRT) can help people who develop a new electrical delay in the heart after having a transcatheter aortic valve replacement (TAVI). The study compares two types of pacing to see which works better for recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- You have had a successful TAVI procedure for severe aortic stenosis without major complications.
- After the TAVI, you developed a new type of heart block (left bundle branch block or LBBB) lasting more than 130 milliseconds, which is still present by day 5 after the procedure.
- Your heart's pumping function is mildly reduced, with an ejection fraction (EF) between 35% and 55% as measured by an ultrasound around the time you are ready to go home.
- You do not have another serious heart valve problem, severe lung disease, or kidney failure needing dialysis.
- You have not had a stroke related to the TAVI procedure and do not have a severe infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a special pacing method for people with heart failure. It aims to improve the heart's pumping by using a more natural pacing approach.
This trial compares two ways to pace the heart after a TAVI procedure for people who need a pacemaker. It aims to find which pacing method works better for preserving heart function.
This study checks if a short, controlled heart pacing procedure right after your TAVI (a valve replacement) can tell doctors whether you might need a permanent pacemaker later. It aims to help avoid unnecessary pacemakers.
This trial compares a newer pacing technique (left bundle branch area stimulation) with standard pacing in people who need a pacemaker after TAVI (a valve replacement procedure). It aims to see if the newer method works better for keeping the heart's rhythm stable.
This trial looks at a physiologic (more natural) heart pacing approach to prevent weakening of the heart’s main pumping chamber after TAVI. It enrolls people who recently had TAVI and now meet standard reasons for needing a permanent pacemaker.
This trial studies people who had a heart valve procedure called TAVI and later had a heart rhythm problem. You will get a tiny heart monitor placed under your skin to track your heart rhythm over time and help doctors understand how common these problems are.
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