Clin2
NCT07439211Likely a fitRecruiting

Testing a new drug combo for acute myeloid leukemia

Leukemia, MyeloidLeukemiaAcute Myeloid LeukemiaRefractory Leukemia

Treatments studied

Part of Blood & lymphatic, Cancer clinical trials.

This trial tests a new drug, eganelisib, combined with azacitidine and venetoclax for patients with acute myeloid leukemia (AML). It's for people whose AML has come back or hasn't responded to treatment, or for those with a high-risk type who haven't been treated yet.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
48 people
Ages
18 years to 90 years
Study type
Interventional

Who can take part

  • You have AML that either came back after treatment, didn't respond to treatment, or is a high-risk type not yet treated.
  • You are between 18 and 90 years old.
  • Your overall health status is fair to good (ECOG score of 0-3 for ages 18-74, or 0-2 for ages 75 and older).
  • Your liver and kidney function are adequate, based on blood tests.
  • You agree to use effective birth control if you or your partner could become pregnant, and for a period after treatment.
  • You can swallow pills and do not have a condition that would affect drug absorption.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06451861Recruiting· Phase 2
Testing a new drug combo for newly diagnosed AML

This trial tests a new combination of drugs (ABC-14) against the standard treatment for adults newly diagnosed with acute myeloid leukemia (AML) who haven't had intensive treatment yet. The goal is to see if the new combo works better and is safe.

Dongguan, Guangdong
NCT07743112Recruiting· Phase 2
Study of a new drug combo for untreated acute myeloid leukemia

This trial tests a new drug, MAX-40279, combined with two standard treatments (venetoclax and azacitidine) for people with newly diagnosed acute myeloid leukemia who are not healthy enough for intensive chemotherapy. The goal is to see if adding this drug improves outcomes.

Tianjin
NCT06504459Recruiting· Phase 2
Testing a drug combo for certain types of AML

This trial tests a combination of chemotherapy drugs (venetoclax, cladribine, cytarabine, and azacitidine) for people newly diagnosed with specific types of acute myeloid leukemia (AML) who cannot have or choose not to have standard intensive chemotherapy.

Miami, Florida
NCT06357182Recruiting· Phase 1
New drug combo for AML patients who can't have strong chemo

This trial tests a new drug combination (iadademstat plus azacitidine and venetoclax) for people with newly diagnosed AML who cannot have or do not want standard intensive chemotherapy. The goal is to see if adding iadademstat makes the treatment work better.

Portland, Oregon
NCT06483906Recruiting· Phase 2
Study of a drug combo and stem cell transplant for high-risk AML

This trial tests a combination of three drugs (venetoclax, azacitidine, and homoharringtonine) followed by a donor stem cell transplant for people with intermediate- or high-risk acute myeloid leukemia (AML). The goal is to see if this approach can improve outcomes for patients who have not been treated before.

Shanghai, Shanghai Municipality
NCT05834244Recruiting· Phase 1
New and relapsed AML treatment using azacitidine, venetoclax, and NK cells

This Phase 1 trial tests a combination of azacitidine, venetoclax, and donor NK cells to treat acute myeloid leukemia (AML) or certain AML-like syndromes. It’s designed mainly to find safe dosing and whether this approach can control the leukemia.

Cleveland, Ohio

Hear when a new Leukemia, Myeloid trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.