New chemo combo for cord blood transplant in older adults
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a special combination of chemotherapy drugs (thiotepa, fludarabine, ara-C, busulfan) and a growth factor (G-CSF) to prepare your body for a transplant using donated umbilical cord blood. It is for older adults (60-69) with blood cancers who cannot use a matched family donor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 60 and 69 years old.
- You have a blood cancer (like leukemia or lymphoma) and are planning to receive a single umbilical cord blood transplant.
- Your heart, lungs, liver, and kidneys are working well (as confirmed by your doctor).
- You are able to take care of yourself (ECOG performance status 0-2).
- You have no serious infections or unstable medical conditions (like recent heart attack or severe heart failure).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a second transplant using two donated umbilical cord blood units for people whose blood cancer returned after a first stem cell transplant. It aims to offer a potential cure for high-risk blood cancers.
This trial tests a cord blood transplant using strong (myeloablative) chemotherapy to prepare your body, plus post-transplant treatment to reduce graft-versus-host disease (GVHD). It may help certain blood cancers when other transplant options are limited.
This study tests whether using umbilical cord blood as a stem cell transplant can improve outcomes for older adults with intermediate- or high-risk acute myeloid leukemia (AML) who are in remission. It may help reduce the risk of the cancer coming back.
This study tests whether using cord blood stem cells (collected from umbilical cords after birth) can help treat high-risk blood cancers in children and young adults when a matched donor is not quickly available. Cord blood transplants may help prevent cancer from coming back.
This trial tests a cord blood transplant after a reduced-intensity chemotherapy and radiation regimen for patients with high-risk blood cancers like leukemia, lymphoma, or MDS. The goal is to see if this approach can help destroy cancer cells and restore healthy blood cells.
This trial tests a combination of drugs (thiotepa, cyclophosphamide, clarithromycin, and cytarabine) before a stem cell transplant. It is for people with certain types of blood cancer who have responded well to earlier treatment.
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