Genetic-guided dosing of 6-MP in childhood ALL maintenance
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests whether giving a personalized dose of the chemotherapy drug 6-MP based on your genetic test results (NUDT15 and TPMT) can be safe and effective for children with ALL during maintenance therapy. It aims to reduce side effects while still keeping the leukemia under control.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with acute lymphoblastic leukemia (ALL) and are in the maintenance phase of treatment.
- You are scheduled to take the oral chemotherapy medicine 6-MP.
- You have had genetic testing (NUDT15 and TPMT) to help guide your 6-MP dose.
- Your liver and kidney function tests are within safe limits (ALT/AST no more than 2.5 times the upper normal limit).
- You do not have Down syndrome, relapsed/refractory ALL, or a history of stem cell transplant.
- You do not have severe organ problems or an uncontrolled infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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