Reducing total body radiation for children with leukemia transplants
Part of Blood & lymphatic, Cancer, Immune system & allergy, Infections clinical trials.
This study looks at whether some children and young adults with B-ALL can safely get a transplant without total body irradiation (TBI), based on special leukemia test results. It’s meant to help lower radiation-related risks while keeping leukemia control strong.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 1 to 25 years for the treatment part (observational may include more cases)
- You must have B-ALL that is in remission (CR1 or CR2) before the transplant
- Your leukemia test (NGS-MRD) must be negative before the transplant for the treatment part
- No prior allogeneic stem cell transplant before this study
- Your transplant plan must be a myeloablative transplant (less intensive conditioning may be observational only)
- You must have healthy enough lungs, kidneys, heart, and liver for transplant chemotherapy
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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