Two immunotherapies before surgery for head and neck cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests a new combination of two immunotherapy drugs (ficerafusp alfa and pembrolizumab) given before surgery for advanced head and neck cancer that can be removed. The goal is to see if this approach can shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a newly diagnosed, advanced head and neck cancer (mouth, throat, voice box, or hypopharynx) that can be removed with surgery.
- Your tumor must be PD-L1 positive (a protein that helps immunotherapy work).
- You haven't had prior treatment with certain immunotherapies or EGFR-targeted drugs.
- You are 18 or older and in generally good health (ECOG 0 or 1, meaning you can do daily activities without much help).
- You are willing to provide blood and tumor samples before and after treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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