Once-daily trientine for first-line Wilson's disease treatment
Part of Brain & nervous system, Digestive system, Genetic & congenital, Hormones & metabolism clinical trials.
This trial tests a once-daily trientine pill as the first treatment for Wilson's disease, a condition where copper builds up in the body. It may help if you've never been treated for Wilson's disease or have only had zinc therapy briefly.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 8 years or older and weigh at least 25 kg (about 55 pounds).
- You have been diagnosed with Wilson's disease (Leipzig score of 4 or higher).
- You have never had treatment for Wilson's disease, or you've had only zinc for up to 28 days.
- You agree to eat a low-copper diet during the study.
- You can swallow pills and don't have severe liver failure or other major health problems.
- You are able to attend study visits and give blood samples.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an experimental mRNA treatment (DSL101) for adults with Wilson disease. It's for people whose condition is stable on current therapy and who have certain genetic markers. The goal is to see if the new treatment can help the body process copper better and reduce the need for standard medicines.
This trial is testing an experimental gene therapy called PM577 that aims to fix the faulty gene causing Wilson disease. It might offer a new treatment option that could reduce or replace the need for daily medications.
This study tests a new gene therapy called LY-M003 that may help people with Wilson's disease by fixing the faulty gene that causes copper buildup. It's for adults who are already on standard treatment and have a confirmed genetic diagnosis.
This trial is a patient registry that collects health information from people with Wilson’s disease, including those without symptoms yet and those taking any type of treatment. It helps researchers understand the disease and how it progresses, which can support future studies and care improvements.
This study follows people who have the genetic cause of Wilson disease, including people who feel well and family members. Researchers want to better understand Wilson disease and what to watch for over time.
This study measures how much copper is present in breast milk in people with Wilson’s disease. It aims to provide safer guidance for breastfeeding during treatment, including during pregnancy.
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