Clin2
NCT07468448Possibly a fitNot yet recruiting

Preventing repeat strokes from narrowed brain arteries

Ischemic StrokeIntracranial Atherosclerosis

Treatments studied

Part of Brain & nervous system, Heart & circulation clinical trials.

This study tests whether a combination of two blood-thinning medications (clopidogrel and rivaroxaban) is better than standard treatment (aspirin alone or aspirin plus clopidogrel) for preventing another stroke in people who have a narrowed artery inside the brain. It aims to reduce the risk of future strokes while managing bleeding risks.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
1,172 people
Ages
40 years and older
Study type
Interventional

Who can take part

  • You must be over 40 years old.
  • You must have had a recent stroke or a high-risk 'mini-stroke' (TIA) with weakness or speech problems.
  • The stroke must be caused by a narrowing in a major artery inside your brain (this condition is called intracranial atherosclerosis).
  • You must be able to start the study treatment within 30 days of your stroke.
  • You must not have a condition that requires long-term blood thinners, and you must not have a high bleeding risk.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06396858Not yet recruiting· Phase 4
Low-dose rivaroxaban for acute ischemic stroke

This study tests a low-dose blood thinner called rivaroxaban, given for 90 days after a recent ischemic stroke, to see if it reduces the risk of another stroke or heart problems. It may be an option for people who are already receiving standard stroke care and are not on full-dose blood thinners.

NCT06571149Recruiting· Phase 4
Blood thinners and clot-busting drugs for stroke

This trial tests whether giving a clot-dissolving medicine (alteplase or tenecteplase) is safe and effective for people who have had a stroke and are taking a blood thinner (DOAC) like apixaban or rivaroxaban. It aims to see if this treatment can still be given within a few hours of the stroke.

Eisenstadt
NCT06790147Not yet recruiting
Stent placement for strokes caused by medication-resistant brain artery narrowing

If you have had a stroke because a brain artery is severely narrowed, despite taking medications to prevent clots, this trial tests placing a small mesh tube (stent) to open the artery and lower the risk of another stroke. It is only for people who have already had a stroke while on medication.

Memphis, Tennessee
NCT06757764Recruiting· Phase 4
Stroke from artery narrowing: testing combination of anti-platelet drugs

This trial tests whether a combination of two or three anti-platelet medicines (like aspirin, clopidogrel, or cilostazol) is safe and works better than one alone for people who had a stroke from a narrowed artery. The goal is to prevent another stroke.

Seoul, Songpa-gu
NCT07746882Not yet recruiting· Phase 3
Comparing blood thinners to prevent another stroke

This study tests two different blood-thinning medicines to see which is better at preventing another stroke in people who recently had a stroke with no clear cause. The goal is to find a treatment that works well and is safe for you.

NCT07237308Not yet recruiting· Phase 4
Two blood thinners compared for stroke with atrial fibrillation

This study tests whether a common blood thinner (apixaban) alone is as safe and effective as combining it with another drug (clopidogrel) to prevent future strokes in people who have both atrial fibrillation and narrowing in the arteries leading to the brain. It aims to find the best way to reduce stroke risk while minimizing bleeding.

Hear when a new Ischemic Stroke trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.