Everolimus for hard-to-treat vascular anomalies
Treatments studied
Part of Cancer, Genetic & congenital, Heart & circulation clinical trials.
This trial tests a pill called everolimus to see if it can shrink or control abnormal blood vessel growths (vascular anomalies) that have not responded to other treatments. It may offer a new option for patients aged 1 year and older.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 1 year old.
- You have a vascular anomaly (a type of abnormal blood vessel growth) that has not improved after at least one prior treatment.
- You have at least one measurable lesion that is 1 cm or larger on an imaging scan (CT or MRI).
- You have an ECOG performance score of 0, 1, or 2, meaning you are mostly able to care for yourself.
- If you are a woman who can become pregnant, you must have a negative pregnancy test and use effective birth control during the study and for 8 weeks after.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a drug called everolimus to see if it helps treat vascular malformations (abnormal clusters of blood vessels). It is for adults aged 18 to 65 who have been diagnosed by MRI and are able to take oral medication.
This Phase 3 study tests whether sirolimus helps control complex vascular anomalies that have not responded to standard treatments. It also checks safety by monitoring blood tests, organ function, and overall health during treatment.
This trial studies whether sirolimus (Rapamune®) can reduce problems from severe arteriovenous malformations (tangled blood vessel connections). It may help shrink the abnormal vessels or improve symptoms, by testing the medicine in people with certain AVM types.
This trial studies whether taking sirolimus once a week can improve blood vessel, lymph vessel, or mixed (venolymphatic) malformations. It may help reduce symptoms and lesion size, while also monitoring safety in children and adults.
This study tests whether the medicine everolimus (taken as a pill) can safely reduce seizures in adults with focal epilepsy that hasn't been controlled by other treatments. You would continue your current seizure medicines and add everolimus.
This trial tests a drug called everolimus for people with advanced colorectal cancer that has a specific change in a gene called CDK12. It aims to see if this drug can slow down the cancer when other treatments have stopped working.
Hear when a new Vascular Malformations trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.