Boosting osimertinib's reach to the brain
Part of Cancer, Lungs & breathing clinical trials.
This trial tests whether adding febuxostat helps the lung cancer drug osimertinib get into the brain better. It is for people with EGFR-mutated NSCLC who are already taking osimertinib, regardless of whether their cancer is stable or slowly progressing.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have metastatic EGFR-mutated lung cancer and are currently taking osimertinib.
- Your cancer is stable or your doctor thinks osimertinib is still helpful even if there's some growth.
- You are willing to have extra blood draws and a lumbar puncture (spinal tap).
- You do not have brain metastases (cancer spread to the brain).
- You have not had a genetic test showing the ABCG2 34G>A variant.
- Your overall health is good enough for daily activities (ECOG score 0-2).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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