Comparing two treatments for liver cirrhosis bleeding and enlarged spleen
Treatments studied
Part of Digestive system clinical trials.
This trial compares a surgery called LSD with a procedure called TIPS to see which is better at preventing rebleeding in people with liver cirrhosis and an enlarged spleen. It may help if you have had bleeding from veins in your esophagus or stomach that came back after treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cirrhosis of the liver that causes high blood pressure in the portal vein.
- You have had severe bleeding from enlarged veins in your food pipe or stomach that returned after a banding procedure.
- You have an enlarged spleen that causes low blood platelets or white blood cells.
- Your liver function is still good enough (Child-Pugh class A or B).
- You are between 18 and 75 years old and willing to give written consent.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a slightly smaller TIPS stent (underdilated) against the standard size to see which is better at preventing another variceal bleed in people with cirrhosis and liver scarring. It aims to find the safest way to lower pressure in the veins while reducing side effects.
This trial compares two approaches to prevent future bleeding from enlarged veins in the esophagus (food pipe) in patients with liver cirrhosis who have already had one bleeding episode. You'll receive either an endoscopic procedure with medication or a minimally invasive vein procedure, to see which works better long-term.
This study tests whether placing a small tube (called a TIPS) early in the liver can help people with cirrhosis who have their first episode of moderate to severe belly fluid buildup. The goal is to see if this early procedure improves outcomes compared to standard care.
This trial tests a procedure to lower blood loss during liver transplant for patients with high blood pressure in the liver. It may help those who have had a previous transplant, abdominal surgery, or certain complications of liver disease.
This study looks at blood clotting in patients with cirrhosis who are getting a TIPS—a tube placed in the liver to help blood flow. The study aims to understand how the procedure affects bleeding and clotting, which could help make it safer for people with liver disease.
This pilot study is testing a new way to guide a TIPS procedure using a special fiber-optic navigation system, which may make the shunt placement more precise for patients with serious liver problems.
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