Pacemaker placement study for heart failure
Part of Heart & circulation clinical trials.
This trial compares two types of pacemaker placement to improve heart function in people with heart failure. One method paces the heart's natural conduction system, while the other paces the lower chambers of the heart. The goal is to find which approach works better for heart resynchronization therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- Your heart's pumping ability is moderately to severely reduced (LVEF 35% or less, or 40% or less if you have a heart block).
- You have symptoms of heart failure (NYHA class II to IV, but class IV only if you are not hospitalized).
- You are on the best possible medications for your heart failure.
- You have a specific type of electrical delay in your heart (left bundle branch block or similar) OR you already have a pacemaker that is pacing your right lower chamber a lot (more than 40% of the time) OR you need a pacemaker for a complete heart block.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a pacing approach designed to improve how the heart beats in some people with heart failure and a specific heart rhythm pattern on ECG. If you already need a device (CRT-D) based on your results, the study may help see whether this pacing correction improves outcomes.
This study tests a new way to place a heart device lead to help the heart beat in sync for people with heart failure and a specific abnormal heart rhythm. The goal is to see if this method improves outcomes compared with standard treatment.
This study compares two pacing methods to help your heart beat in sync. If you need a cardiac resynchronization therapy (CRT) device, this trial will see if a newer pacing method is just as good as the standard one.
This trial tests whether a different pacing approach called left bundle branch pacing can improve outcomes and heart structure changes in people who did not improve with standard biventricular CRT. It may help some patients with ongoing heart failure symptoms and weak heart pumping.
This study compares two ways to place a pacemaker lead in the heart for people who have heart failure and a type of irregular heartbeat called atrial fibrillation. The goal is to see which pacing method helps the heart pump blood better.
This trial is for people with a standard pacemaker that stimulates the right ventricle most of the time. It tests whether a newer type of pacemaker (CRT) can improve heart function and symptoms. If you have a weakened heart (LVEF between 35-50%) and your heart failure has gotten worse, this study may be a good fit.
Hear when a new Cardiac Resynchronisation Therapy (CRT) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.