A study on bone marrow plus IV antibiotics for bacterial meningitis
Treatments studied
Part of Brain & nervous system, Infections clinical trials.
This trial tests if adding antibiotics directly into the skull bone marrow, along with standard IV antibiotics, helps people with moderate-to-severe bacterial meningitis who are not getting better after 2-3 days of regular treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must have moderate to severe bacterial meningitis, with a low GCS score (12 or less) or a recent drop of at least 2 points.
- You must have at least one serious symptom like confusion, seizures, or need for a breathing machine.
- Standard antibiotics have not helped your condition after 48 to 72 hours.
- You might need treatment with strong antibiotics like vancomycin, tigecycline, or polymyxin B.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at the best way to treat meningitis in adults right away and then checks how people recover over time. It aims to improve care and recovery for patients.
This trial focuses on people in Denmark who may have an infection in the brain or the fluid around the brain and spinal cord. Researchers aim to collect and compare diagnostic results for different infection types (viral meningitis, bacterial meningitis, encephalitis, and others) to help confirm the cause and guide care.
This trial is for adults with a serious brain infection caused by drug-resistant bacteria. It tests giving an antibiotic (polymyxin B) directly into the brain through a drain tube to see if it works better.
This trial looks at whether continuing treatment for a bacterial brain abscess using partially oral antibiotics works as well as the usual approach. It may help people who have already had 14 days of antibiotic treatment and are stable enough to take medicines by mouth.
This study enrolls children and newborns with suspected or confirmed bacterial meningitis. The goal is to understand and improve care for serious infections that affect the lining around the brain.
This trial tests if adding a bone-strengthening drug (bisphosphonate) to standard antibiotic treatment (vancomycin) works better for a certain type of long-term bone infection (osteomyelitis) that needs surgery. It may help people with a staph infection in their thigh or shin bone who are otherwise fairly healthy.
Hear when a new Blood-Brain Barrier trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.