Combining antibiotics with skull delivery for severe brain infection
Treatments studied
Part of Brain & nervous system, Infections clinical trials.
This trial tests a new way to give antibiotics for severe brain infections that are not improving with standard treatment. The drugs are delivered into the skull bone to target the infection directly, which may help when usual IV antibiotics are not working.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed brain infection (meningitis) that is not getting better with antibiotics.
- You have a low score on a consciousness check (Glasgow Coma Scale 12 or less), or your score has dropped by 2 or more points.
- You have at least one sign such as confusion, seizures, or need for a breathing tube.
- You are already being treated with antibiotics like polymyxin B, tigecycline, or vancomycin, or your doctor plans to start them.
- You must be willing to give written consent to participate.
- You must not have certain conditions like severe bleeding risk, major organ failure, or infections elsewhere that are the main cause of illness.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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