Pre-surgery drug combo for stage IIB/III acral melanoma
Part of Cancer, Skin clinical trials.
This study tests whether giving a combination of an immunotherapy drug (pucotenlimab) with two other drugs (lenvatinib and temozolomide) before surgery can help shrink melanoma and reduce the chance of it coming back. The treatment is given before you have surgery to remove the melanoma.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- Your melanoma is stage IIB or III and can be removed with surgery.
- You have not had any drug treatment for melanoma before (like immunotherapy or chemotherapy).
- You are generally healthy with good kidney, liver, heart, and blood counts.
- You do not have an active autoimmune disease or a history of significant bleeding problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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