Testing targeted therapy combos for EGFR-mutant lung cancer
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a combination of two targeted therapies (amivantamab and lazertinib) or amivantamab with chemotherapy for people with advanced lung cancer that has a specific EGFR mutation. It aims to see if these treatments work better together than current options.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 19 or older.
- Your lung cancer must have a specific EGFR mutation (exon 19 deletion or L858R).
- Your cancer must be locally advanced, recurrent, or metastatic (spread or come back).
- You should be able to swallow pills.
- You need to be in fairly good health overall, with no serious heart, lung, or liver problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study follows patients with advanced lung cancer (a type called non-small cell lung cancer) who are receiving a combination of chemotherapy and a drug called amivantamab. Researchers want to understand how well this treatment works and track your health outcomes over time.
This trial tests a combination of two targeted drugs (DZD9008 and AZD4205) for people with advanced non-small cell lung cancer that has a specific EGFR mutation and has stopped responding to standard treatments. The goal is to see if this combination can shrink tumors or slow cancer growth.
This trial tests combining an EGFR-targeted pill (like osimertinib) with the intravenous drug bevacizumab for people with advanced non-small cell lung cancer that has an EGFR mutation and has not been treated before. The goal is to see if this combination works better when guided by a special blood test that finds cancer cells.
This trial tests a new targeted drug (limertinib) plus chemotherapy (carboplatin and etoposide) for people whose EGFR-mutant lung cancer has changed into small cell lung cancer (SCLC) after prior targeted therapy. The goal is to see if this combination can shrink tumors or slow the cancer's growth.
This trial tests two treatment combinations for people with a specific type of advanced lung cancer that has an EGFR mutation. One group gets amivantamab plus lazertinib, and the other gets amivantamab plus chemotherapy. The goal is to see which combo works better.
This trial tests whether the drug amivantamab combined with a single chemotherapy drug can help people with advanced non-small cell lung cancer that has a specific EGFR gene mutation (exon20 insertion). It is for people who cannot safely receive standard platinum-based chemotherapy.
Hear when a new Non Small Cell Lung Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.