New skull bone injection for severe stroke treatment
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a new way to deliver a medication called RK-4 directly into the skull bone marrow to bypass the blood-brain barrier for people with a major stroke on one side of the brain. The goal is to see if this injection is safe and feasible, and it might help reduce damage after a severe stroke.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 80 years old.
- You should have been independent before this stroke and have no prior major disability.
- Treatment must start within 24 hours of when your stroke began (or when you were last seen well).
- You must have a specific type of large stroke affecting the middle brain area, with moderate-to-severe symptoms (NIHSS 16-32).
- No brain bleeding, no other serious brain conditions, and no recent skull fractures or infections.
- You cannot have severe liver or kidney problems, uncontrolled blood pressure, or other serious medical conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether injecting a special solution (RK-4) into the skull can help people with a severe type of stroke caused by a blockage in a major brain artery. The treatment aims to reduce brain damage and improve recovery when given within 24 hours of the stroke.
This trial tests an investigational injection called KPCXM18 for people having an acute ischemic stroke. It is given within 12 hours of symptom onset, in addition to standard clot-dissolving treatment, to see if it improves recovery and safety.
This trial tests an experimental treatment called RK-4 that is given directly into the bone of the skull shortly after a severe stroke. The goal is to see if it can improve recovery and reduce disability from a major stroke on one side of the brain.
This trial tests a new way to give medicine for a large stroke on one side of the brain. The medicine is injected into the skull bone instead of through a vein, and researchers want to see if it works better and is safe.
This trial tests an investigational drug, QHRD106, given as an injection for people who have had a moderate-to-severe acute ischemic stroke. It aims to see if the drug can help recovery when given within 24 hours after the stroke starts, and it is for patients who are not receiving standard clot-busting treatment.
This trial tests whether a drug called urinary kallidinogenase can help people who have had a stroke caused by a blocked artery in the brain. The drug is given within 48 hours of the stroke, and the study hopes to see if it improves recovery and reduces disability.
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