New Brain Treatment for Large Stroke Using Skull Injection
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a new drug (RK-4) delivered directly through the skull bone to treat patients with large strokes in the brain's main blood vessel. The goal is to see if this approach is safe and can help restore brain function when standard stroke treatments aren't working well enough.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–80 years old
- First stroke or fully independent before this stroke (able to care for yourself)
- Received treatment within 24 hours of stroke symptoms starting
- Large stroke in the middle part of the brain with moderate-to-severe symptoms (NIHSS score 16–32)
- Stroke symptoms not improving enough after standard clot-removal therapy
- No bleeding in the brain, no skull fractures in last 3 months, and stable vital signs
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a new drug, RK-4, given via injection into the skull for people who have had a major stroke. It's for those who have not improved enough after standard treatment like clot removal.
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This trial tests a new way to give medicine for a large stroke on one side of the brain. The medicine is injected into the skull bone instead of through a vein, and researchers want to see if it works better and is safe.
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