Second CAR-DC Cell Infusion for Advanced Heart Failure
Part of Genetic & congenital, Heart & circulation clinical trials.
This trial tests a second dose of specialized immune cells (called CAR-DC) in patients with severe dilated cardiomyopathy (a weakened heart muscle) who received one dose before but saw their heart function decline back to baseline. The goal is to see if a second dose is safe and can improve heart function when the first treatment's benefits wore off.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18–75 years old and have been diagnosed with dilated cardiomyopathy (a weakened, enlarged heart)
- You received one infusion of CAR-DC therapy at least 6 months ago, but your heart function has declined back to pre-treatment levels despite the first treatment
- You have severe heart failure symptoms (NYHA Class III–IV, meaning limited or no physical activity without symptoms) and low heart pumping ability (ejection fraction below 35%)
- Your blood counts are healthy enough for the procedure: hematocrit above 30%, lymphocytes above 0.5 × 10⁹/L, and platelets above 60 × 10⁹/L
- You do not have severe kidney disease, liver disease, active infections (including hepatitis B, C, HIV, or syphilis), or severe shock
- You understand the risks and benefits and agree to participate with written informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new treatment called FAP iCDC for people with end-stage dilated cardiomyopathy, a type of heart muscle disease. It aims to see if this therapy is safe and helps improve heart function when standard medicines are no longer enough.
This trial tests a protein filtering treatment (immunoadsorption) for people with dilated cardiomyopathy who have a specific antibody linked to heart damage. It aims to see if removing these antibodies can improve heart function.
This trial tests a treatment made from stem cells that are turned into heart muscle cells and injected directly into the heart. It is for people with advanced heart failure who are already on the best available medicines and who are scheduled to have bypass surgery.
This trial tests whether heart muscle cells made from stem cells, injected into the heart, can improve heart function in people with heart failure and a weak heart pump. It may be an option for those who are not getting enough help from other treatments.
This early-phase study tests a new type of immune cell therapy (CAR-DC) for people with advanced heart failure due to blocked arteries. It aims to see if the treatment is safe and may help improve heart function.
This trial tests a new type of cell therapy (FAP iCDC) for people who have had a severe heart attack that caused their heart to pump too weakly (cardiogenic shock). The goal is to see if this treatment can help the heart recover better after the artery has been opened.
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