Gentle lung breathing with heart-lung machine support for severe lung failure
Part of Lungs & breathing clinical trials.
This trial tests a combination of very gentle breathing settings on a ventilator paired with a temporary heart-lung machine (ECMO) to help patients with severe acute respiratory distress syndrome (ARDS) recover. The goal is to protect your lungs from further injury while they heal.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Currently on a breathing tube and ventilator for 7 days or less
- Severe lung injury confirmed in the last 48 hours with specific blood oxygen and chest imaging findings
- Lungs showing signs of stiffness or difficulty removing carbon dioxide (measured by specific ventilator settings)
- 18 years or older and not pregnant or breastfeeding
- Able to receive blood-thinning medication and have a special catheter placed in a large vein
- No severe heart disease, recent heart attack, or serious blood clotting disorders
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a new way to adjust the amount of air given by the ventilator to people with a severe lung injury called ARDS. The goal is to see if a specific breathing strategy can help protect the lungs and improve recovery.
This study looks at how the immune system and ECMO (a machine that helps oxygenate blood) can improve outcomes for people with moderate to severe ARDS. If you join, researchers will monitor your condition and treatment to find better ways to manage this serious lung problem.
This study tests whether a gentler, low-blood-flow version of ECMO (a machine that helps oxygenate blood outside the body) is safe and effective for adults with very severe breathing failure. It is for patients who are already on a breathing machine and have very low oxygen levels despite that support.
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This trial is for people with severe lung failure (ARDS) who are already on a life-support machine called VV-ECMO. It tests whether adding a special breathing tube (CPAP) can help their lungs heal better.
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