Study of Denikitug with immunotherapy or chemotherapy for advanced colorectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a new drug called denikitug, given alone or combined with other cancer treatments, for patients with advanced colorectal cancer that hasn't responded to previous treatments. The goal is to help people whose cancer has a specific genetic profile (MSS) that doesn't respond well to standard immunotherapy alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Advanced colorectal cancer that cannot be surgically removed, has come back, or has spread to other parts of the body
- Cancer cells must have a specific genetic pattern called MSS (microsatellite stable) or pMMR, confirmed by laboratory testing
- You have received 1–2 previous treatment regimens for advanced cancer, including certain chemotherapy drugs
- Your cancer has grown or worsened during or after your most recent treatment
- Good overall health and ability to perform daily activities with minimal assistance (ECOG score 0–1)
- Adequate heart, liver, and kidney function based on recent blood tests
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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