Stem cell treatment vs. hyaluronic acid for knee arthritis
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study tests whether an injection of stem cells (special cells that can help repair tissue) works better than a standard hyaluronic acid injection for knee osteoarthritis pain. Both treatments are injected into the knee to reduce pain and improve function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18 or older
- Diagnosed knee osteoarthritis confirmed by X-ray within the last 3 months
- Knee pain during activity rated 40 or higher on a 0–100 pain scale
- BMI between 18.5 and 35.0 (healthy weight range)
- No major knee ligament tears or severe knee instability
- No recent meniscus surgery (less than 9 months ago), infections, or inflammatory joint disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study compares a new treatment made from stem cell secretions (called secretome) with a standard knee injection (hyaluronic acid) to see which works better for knee osteoarthritis pain.
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This Phase 2 study tests whether injected umbilical-cord stem cells can improve safety and reduce symptoms in people with moderate knee osteoarthritis. It focuses on people with significant knee pain who have not gotten enough relief from standard, non-procedure treatments.
This study tests whether special stem cells (called UC-MSCs, derived from umbilical cord tissue) can reduce pain and improve function in people with moderate knee osteoarthritis. Researchers will inject these cells into your knee to see if they help repair damaged cartilage and reduce inflammation.
This study tests whether a hyaluronic acid injection (a natural lubricant for joints) can reduce inflammation markers in the knee for people with osteoarthritis. It may be a good option if you have moderate knee pain that hasn't improved with other treatments.
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