Esketamine injection to reduce itching after cesarean delivery
Treatments studied
Part of Skin clinical trials.
This trial tests whether a single injection of esketamine (a type of anesthetic medication) given during planned cesarean delivery can reduce severe itching caused by intrahepatic cholestasis of pregnancy (a liver condition that develops during pregnancy). If you have this condition and are scheduled for cesarean delivery, this study may help relieve your itching.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18–40 years old and at least 35 weeks pregnant with a single baby
- You have been diagnosed with intrahepatic cholestasis of pregnancy (confirmed by blood test results)
- You have had severe itching (rated 4 or higher on a 0–10 scale) at least twice in the past week
- You are planning to have a cesarean delivery under spinal anesthesia (numbing medication injected in your lower back)
- You are in overall good or fair health (ASA classification I–III, meaning no severe organ damage)
- You have not participated in another drug trial in the past 4 weeks
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if the drug maralixibat can help women with a liver condition called intrahepatic cholestasis of pregnancy (ICP) that causes severe itching and high bile acids. If you are between 20 and 35 weeks pregnant with one healthy baby and have high bile acids, you may be able to join.
This trial tests whether giving a medicine called esketamine during surgery reduces severe itching caused by blocked bile ducts. It may help people having operations like gallbladder or bile duct surgery feel less itchy afterward.
This trial tests whether a medication called esketamine, given during knee replacement surgery, can help reduce chronic itching in older adults. Chronic itching affects many seniors and can significantly impact quality of life.
This trial tests whether a medicine called esketamine (given during anesthesia) can help reduce anxiety, sadness, or other negative emotions that often occur before and after breast cancer surgery. This could help you feel better emotionally during your recovery.
This study tests whether a nasal spray containing two medications (esketamine and dexmedetomidine) can help prevent postpartum depression in pregnant women who show early signs of depression. Postpartum depression is common and can be serious, so this trial explores a new way to treat it right around the time of delivery.
This trial tests if giving ondansetron before spinal anesthesia can prevent itching that often happens after a C-section. It may help you feel more comfortable during recovery.
Hear when a new Intrahepatic Cholestasis of Pregnancy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.