Esketamine during cesarean for itching in pregnancy liver condition
Treatments studied
Part of Skin clinical trials.
This study tests whether a single injection of esketamine (a pain medicine related to ketamine) given during a cesarean section can reduce itching after the surgery in women with a pregnancy-related liver condition. If it works, it could help you feel more comfortable after your baby is born.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 40 years old and at least 35 weeks pregnant with one baby.
- You have been diagnosed with intrahepatic cholestasis of pregnancy (ICP), which causes itching and high bile acid levels.
- You have had itching that you rate as at least 4 out of 10 on two occasions within the past week.
- You are scheduled to have a cesarean section with spinal anesthesia (numbing from the waist down).
- You are generally healthy (classified as ASA I–III) and do not have certain other conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This study tests whether giving a medicine called esketamine during your surgery helps reduce severe itching that comes from liver or bile duct problems. If you are already scheduled for this type of surgery, the medicine may give you extra relief from itching after the operation.
This study tests if a low-dose medication called esketamine, given during knee replacement surgery, can reduce the itching you may feel afterward. The medication is added to the anesthesia to see if it helps with itching in older adults.
This study tests whether giving two medicines as a nasal spray around the time of childbirth can help prevent or reduce postpartum depression. It may help women who already have some depression symptoms during pregnancy feel better after giving birth.
This trial tests whether a medicine called esketamine, given during breast cancer surgery, can help reduce negative emotions like anxiety or depression before and after the operation. It may help you feel more emotionally stable during your treatment.
This study tests whether ketamine, a medicine given during cesarean delivery, can help prevent or reduce postpartum depression and pain. It aims to find the best dose for new mothers.
This study tests whether a gentle brain stimulation technique (tDCS) can reduce itching after a C-section. It is for women who are having a C-section with epidural anesthesia and morphine.
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