Extra chemotherapy before local surgery for early rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests whether adding more chemotherapy before a less invasive surgery (local excision) can help people with early-stage rectal cancer avoid more extensive surgery, while still controlling the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with rectal cancer (a type of cancer in the rectum).
- The tumor is in the lower part of the rectum, within 15 cm from the anal verge.
- You have stage I rectal cancer: either cT2N0 (tumor invades muscle but no lymph node spread) or, if you had a prior endoscopic removal, the tumor was stage T1N0 but had a high-risk feature like positive margin, lymphovascular invasion, or tumor budding.
- You are not planning to have radical rectal surgery, and you have not had surgery for rectal cancer before.
- Your cancer has not spread to lymph nodes or other parts of the body (no metastasis).
- You are generally healthy, with no uncontrolled infections or medical conditions, and no known allergy to chemotherapy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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