CAR T-Cell Therapy for Hard-to-Treat Lupus Kidney Disease
Part of Immune system & allergy, Kidney & urinary, Skin, Women’s health & pregnancy clinical trials.
This trial tests FT819, a new type of immune cell therapy (CAR T cells), for people with lupus nephritis—kidney inflammation caused by lupus—who haven't responded well to standard treatments. The goal is to see if this therapy can reduce kidney damage and improve kidney function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 12 and 70 years old
- You have been diagnosed with systemic lupus erythematosus (SLE, or lupus) and have kidney involvement (lupus nephritis)
- A kidney biopsy shows a specific type of kidney inflammation (proliferative Class III or IV lupus nephritis)
- Blood tests show lupus antibodies (ANA, anti-dsDNA, or anti-Smith antibody)
- Your lupus kidney disease is active and hasn't improved after trying at least 2 different immunosuppressive medications
- Your kidney function is low enough to show active disease, but not so damaged that doctors think treatment cannot help
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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