Clin2
NCT07578467Possibly a fitNot yet recruiting

Combining study drug with radiation for early throat cancer

HPV Positive Oropharyngeal Squamous Cell CarcinomaSquamous Cell CarcinomaHPV (Human Papillomavirus)-Associated CarcinomaHPV Associated CancersOropharyngeal HPV Squamous Cell Carcinoma

Part of Cancer, Infections clinical trials.

This study tests a new drug (ATRN-119) combined with focused radiation before surgery for people with early-stage HPV-positive throat cancer. It aims to see if this combination can shrink tumors and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
35 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have been diagnosed with HPV-positive throat cancer at an early stage (stage I or II).
  • Your overall health is good enough, based on blood tests for calcium, kidney, and liver function.
  • You are not pregnant or breastfeeding, and you agree to use effective birth control if applicable.
  • You have not had major surgery within 7 days before starting the study drug, and you are not taking certain medications that interact with the study drug.
  • You do not have another active cancer, uncontrolled infections, or serious medical conditions that would make the study unsafe.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07628062Not yet recruiting· Phase 2
Vaccine and drugs before reduced radiation for HPV throat cancer

This study tests a new combination of drugs and a vaccine before standard radiation for HPV-positive throat cancer. It aims to use a less intense radiation dose, which may reduce side effects while still being effective.

NCT07418034Not yet recruiting· Phase 2
Lower radiation doses for HPV-related throat cancer

This trial tests whether giving lower doses of radiation to certain parts of the throat can be just as effective as standard doses, while reducing side effects. It is for people with HPV-positive throat cancer, which tends to respond well to treatment.

NCT05600842Recruiting
Lower-dose radiation for HPV-positive throat cancer

This trial tests whether using a de-escalated (lower/intensity-reduced) radiation approach can treat HPV-positive oropharyngeal squamous cell carcinoma. It may help reduce side effects while still keeping the cancer under control.

Orange, California
NCT06759155Not yet recruiting· Phase 2
Less intense therapy for HPV-positive throat cancer

This trial tests a less intense treatment plan for HPV-positive throat cancer that is caught early or moderately advanced. The goal is to keep the cancer from coming back while reducing side effects from standard therapy.

NCT05307939Recruiting· Phase 2
Using tumor DNA tests to time treatment for HPV throat cancer

This study checks a blood test that looks for HPV tumor DNA to help doctors decide when to start routine treatment after surgery. It may help some people avoid starting treatment too early or too late based on how the test changes after the operation.

Miami, Florida
NCT07497607Recruiting· Phase 2
Lower radiation dose for HPV-positive throat cancer

This trial tests a lower dose of radiation to certain neck areas for people with HPV-related oropharyngeal cancer. The goal is to see if reducing radiation can cause fewer side effects while still curing the cancer.

Cincinnati, Ohio

Hear when a new HPV Positive Oropharyngeal Squamous Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.