Clin2
NCT07597070Possibly a fitNot yet recruiting

Adding a covid-19 vaccine to immunotherapy for advanced lung cancer

Stage 4 NSCLC

Part of Cancer, Lungs & breathing clinical trials.

This trial tests whether adding a COVID-19 vaccine to standard immunotherapy treatment can help boost the immune system to fight lung cancer more effectively. It is for people with advanced non-small cell lung cancer who are starting pembrolizumab plus chemotherapy for the first time.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
500 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have stage IV non-small cell lung cancer (a type of lung cancer that has spread), and you are about to start your first treatment with pembrolizumab (an immunotherapy drug) plus chemotherapy.
  • You are able to care for yourself and are up and about at least half of the day (ECOG score 0-2).
  • You are willing to receive the Pfizer-BioNTech COVID-19 vaccine as part of the study.
  • If you can become pregnant, you agree to use effective birth control during treatment and for 5 months after.
  • The study is not for people receiving targeted therapy for certain gene changes (EGFR, ALK, ROS1) or who are allergic to mRNA vaccines.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07715396Not yet recruiting· Phase 3
Adding chemotherapy to immunotherapy for advanced lung cancer

This study tests whether adding a type of chemotherapy called platinum-based chemo to an immunotherapy drug called tislelizumab helps people with advanced non-small cell lung cancer that has spread and has high PD-L1. The trial aims to see if this combination works better than immunotherapy alone in people with larger tumors.

Frankfurt
NCT05344209Recruiting· Phase 2
Pembrolizumab plus or minus vaccine for advanced lung cancer

This Phase 2 trial studies pembrolizumab (an immune-boosting cancer medicine) alone or with an added investigational UV1 vaccine in people with advanced non-small cell lung cancer. It aims to see whether adding the vaccine improves safety and effectiveness, especially in tumors with high PD-L1 levels.

Drammen, Akershus
NCT06561386Recruiting· Phase 3
Testing a new drug combo for advanced lung cancer

This trial is comparing a new combination of two immunotherapy drugs (nivolumab and relatlimab) plus chemotherapy against the standard immunotherapy (pembrolizumab) plus chemotherapy for people with advanced non-squamous non-small cell lung cancer that has a certain protein (PD-L1) on at least 1% of its cells. The goal is to see if the new combination works better.

Mobile, Alabama
NCT07222566Recruiting· Phase 3
New drug plus chemotherapy for advanced lung cancer

This trial tests a new study drug called PF-08634404 combined with standard chemotherapy for people with advanced lung cancer that has not been treated before. It aims to see if this combination works better than chemotherapy alone.

Bullhead City, Arizona
NCT04253964Recruiting· Phase 2
Chemotherapy plus immunotherapy for advanced lung cancer

This study tests a combination of chemotherapy and immunotherapy in people with advanced non-small cell lung cancer that has spread or cannot be removed with surgery. The goal is to see how well this treatment works in patients with different levels of daily activity.

Charlotte, North Carolina
NCT04297605Recruiting· Phase 1
Pembrolizumab plus chemotherapy for advanced lung cancer

This Phase 1 study tests pembrolizumab (an immunotherapy) given together with a chemotherapy drug to treat non-small cell lung cancer that is locally advanced or has spread. It’s aimed at people who can handle treatment with an ECOG performance status of 2, including some with certain types of brain metastases.

Rochester, New York

Hear when a new Stage 4 NSCLC trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.