Medications to improve sleep after knee replacement
Part of Bones, joints & muscles, Pain clinical trials.
This study tests whether a medication called doxepin, alone or with ramelteon, can help you sleep better after your knee replacement surgery, compared to a placebo (a pill with no active medicine). You would take the medication for a short time after surgery to see if it improves your sleep quality.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You are planning to have a total knee replacement (total knee arthroplasty).
- You do not have a heart condition called bundle branch block.
- You are not taking certain antidepressants (SSRIs, SNRIs, MAOIs) or receiving treatment for major depression, anxiety, bipolar, or psychotic disorder.
- You have not used prescription painkillers (narcotics) more than once in the past 3 months.
- You have not used prescription sleep aids (like Ambien) before surgery, and you do not have a history of a major sleep disorder (like sleep apnea, restless legs, or narcolepsy).
- You are not pregnant, breastfeeding, or planning to become pregnant in the next 3 months.
- You have not had glaucoma-related procedures or are not currently using glaucoma eye drops.
- You do not have severe urinary retention or difficulty emptying your bladder.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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