Best treatment for acid reflux affecting your throat
Treatments studied
Part of Digestive system, Ear, nose & throat clinical trials.
This study compares five different treatments for laryngopharyngeal reflux—acid that comes up from your stomach and irritates your throat and voice box. Researchers will test which approach works best: three over-the-counter antacids, a prescription acid-blocking medicine, or dietary changes alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have confirmed acid reflux affecting your throat (shown by a 24-hour pH test with more than 1 reflux event)
- You do not smoke more than 5 cigarettes per day
- You do not have alcohol dependence (drinking more than 3 units daily)
- You have not had an upper respiratory infection in the past month
- You are not pregnant
- You do not have a history of neck surgery, trauma, cancer, or head/neck radiation therapy
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how stomach acid backing up into the throat can change the voice. It may help find typical voice differences in people with acid reflux.
This study tests how well omeprazole (a common acid-blocking medicine) works for people with laryngopharyngeal reflux (LPR), a condition where stomach acid irritates the throat. If you have had throat symptoms for more than 8 weeks and are already scheduled for an endoscopy with acid monitoring, you may qualify to see if this medicine helps more than a placebo.
This study tests whether giving a common acid-reducing medicine (a proton pump inhibitor) to children with laryngomalacia can reduce choking and aspiration. It may help if your child has frequent choking episodes.
This study looks at the “upward reflux” that can irritate the throat and sometimes worsen symptoms like cough or asthma. It aims to understand the mechanisms that prevent or allow throat reflux, which may lead to better ways to manage symptoms.
This trial tests a new way to treat GERD (chronic acid reflux) using a tiny camera and a device that delivers a gentle heat treatment (argon plasma coagulation) to the area where the stomach meets the esophagus. It's compared to a 'sham' procedure (you won't know which you get) to see if it stops acid from backing up better than medicine alone.
This Phase 2 study tests whether fosamprenavir can reduce inflammation and enzyme activity in the throat area for people with laryngopharyngeal reflux (LPR). If you still have LPR symptoms despite 3 months of twice-daily reflux medicine, this trial may offer another treatment approach.
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