Comparing treatments for silent reflux
Treatments studied
Part of Digestive system, Ear, nose & throat clinical trials.
This study compares different treatments for laryngopharyngeal reflux (often called 'silent reflux') to see which works best. It may help find the most effective option for your symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed diagnosis of laryngopharyngeal reflux (often called 'silent reflux') using a special 24-hour acid-monitoring test.
- You should not smoke more than 5 cigarettes per day.
- You should not drink more than 3 units of alcohol per day (for example, more than 3 glasses of wine or beer).
- You must not have had a respiratory infection (like a cold or sinus infection) in the last month.
- You must not be pregnant, have a neurological or psychiatric condition, a history of neck surgery or injury, cancer, or have had radiation to the head or neck.
- You must not have active seasonal allergies or asthma.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests how well omeprazole (a common acid-blocking medicine) works for people with laryngopharyngeal reflux (LPR), a condition where stomach acid irritates the throat. If you have had throat symptoms for more than 8 weeks and are already scheduled for an endoscopy with acid monitoring, you may qualify to see if this medicine helps more than a placebo.
This study looks at the “upward reflux” that can irritate the throat and sometimes worsen symptoms like cough or asthma. It aims to understand the mechanisms that prevent or allow throat reflux, which may lead to better ways to manage symptoms.
This study checks whether a special test of the esophagus after meals can find the exact reason for ongoing reflux symptoms when proton pump pills (PPIs) don’t help. It may help doctors choose the right next treatment for people whose reflux symptoms keep coming back.
This trial tests a new way to treat GERD (chronic acid reflux) using a tiny camera and a device that delivers a gentle heat treatment (argon plasma coagulation) to the area where the stomach meets the esophagus. It's compared to a 'sham' procedure (you won't know which you get) to see if it stops acid from backing up better than medicine alone.
This trial tests a new endoscopic procedure called anti-reflux mucosal ablation therapy to reduce acid reflux in people who still have symptoms despite taking acid-reducing medication. The goal is to see if this treatment helps improve heartburn and related symptoms.
This study looks at how following specific diet and behavior changes affects symptoms of acid reflux (heartburn/regurgitation) in everyday life. It may help you understand what lifestyle steps improve reflux and how symptoms change over time.
Hear when a new Laryngopharyngeal Reflux Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.