The Mechanism Versus PPI Trial for throat reflux
Treatments studied
Part of Brain & nervous system, Digestive system, Ear, nose & throat, Lungs & breathing clinical trials.
This study tests how well omeprazole (a common acid-blocking medicine) works for people with laryngopharyngeal reflux (LPR), a condition where stomach acid irritates the throat. If you have had throat symptoms for more than 8 weeks and are already scheduled for an endoscopy with acid monitoring, you may qualify to see if this medicine helps more than a placebo.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 89 years old.
- You have had throat symptoms like coughing, hoarseness, or clearing your throat for more than 8 weeks.
- You are scheduled for an upper endoscopy (a scope to look at your throat and stomach) and a test to monitor stomach acid, and you must not take any acid-blocking medicine for at least 2 weeks before the study starts.
- You cannot have had prior surgery on your throat or stomach.
- You cannot currently use tobacco or be pregnant or nursing.
- You must be able to attend study visits in person in San Diego.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests whether fosamprenavir can reduce inflammation and enzyme activity in the throat area for people with laryngopharyngeal reflux (LPR). If you still have LPR symptoms despite 3 months of twice-daily reflux medicine, this trial may offer another treatment approach.
This trial tests a new way to treat GERD (chronic acid reflux) using a tiny camera and a device that delivers a gentle heat treatment (argon plasma coagulation) to the area where the stomach meets the esophagus. It's compared to a 'sham' procedure (you won't know which you get) to see if it stops acid from backing up better than medicine alone.
This study looks at the “upward reflux” that can irritate the throat and sometimes worsen symptoms like cough or asthma. It aims to understand the mechanisms that prevent or allow throat reflux, which may lead to better ways to manage symptoms.
This trial tests a new medicine, JP-1366, for people with non-erosive GERD (heartburn and acid reflux without visible damage to the esophagus). The goal is to see if it helps control symptoms better than a placebo.
This study tests whether a probiotic called Lactobacillus rhamnosus GG can improve gut bacteria changes caused by proton pump inhibitors (acid-reducing medicines). It mainly involves people who are otherwise healthy and do not currently have ongoing stomach or gut symptoms.
This study checks whether a special test of the esophagus after meals can find the exact reason for ongoing reflux symptoms when proton pump pills (PPIs) don’t help. It may help doctors choose the right next treatment for people whose reflux symptoms keep coming back.
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