The Mechanism Versus PPI Trial for throat reflux
Treatments studied
Part of Brain & nervous system, Digestive system, Ear, nose & throat, Lungs & breathing clinical trials.
This study tests how well omeprazole (a common acid-blocking medicine) works for people with laryngopharyngeal reflux (LPR), a condition where stomach acid irritates the throat. If you have had throat symptoms for more than 8 weeks and are already scheduled for an endoscopy with acid monitoring, you may qualify to see if this medicine helps more than a placebo.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 89 years old.
- You have had throat symptoms like coughing, hoarseness, or clearing your throat for more than 8 weeks.
- You are scheduled for an upper endoscopy (a scope to look at your throat and stomach) and a test to monitor stomach acid, and you must not take any acid-blocking medicine for at least 2 weeks before the study starts.
- You cannot have had prior surgery on your throat or stomach.
- You cannot currently use tobacco or be pregnant or nursing.
- You must be able to attend study visits in person in San Diego.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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