Nesiritide to prevent kidney injury during heart surgery
Part of Kidney & urinary, Women’s health & pregnancy clinical trials.
This study tests whether a medication called nesiritide (a heart-supportive drug) can prevent kidney damage that sometimes occurs after heart surgery with a heart-lung machine. Patients at higher risk for this kidney injury are being enrolled to see if the medication helps protect their kidneys.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and scheduled for planned heart surgery using a heart-lung machine
- You have at least one risk factor for kidney problems: age 70+, reduced kidney function, type 2 diabetes, or heart failure
- You do not have severe kidney disease, active infections, or recent emergency treatments requiring machines to support your heart
- Your liver is working reasonably well and you do not have hepatitis, HIV, syphilis, or active cancer
- You have not had a severe allergic reaction to nesiritide or been in another drug trial in the past month
- You are not pregnant, breastfeeding, or on dialysis or other kidney replacement therapy
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial is testing whether a single dose of the steroid methylprednisolone, given before heart surgery, can protect your kidneys from damage during the operation. If you qualify, you'll receive the drug or a placebo, and your kidney function will be monitored closely.
This study tests a device called RenalGuard to see if it can prevent acute kidney injury in people having heart surgery. If you are at higher risk for kidney problems, this treatment might help protect your kidneys during and after surgery.
This study looks at how well the kidneys and body handle stress during heart surgery. By checking blood tests before and after the operation, researchers aim to find ways to protect kidney function.
This study tests a new medicine, BX-001N, to see if it can prevent kidney damage during and after heart surgery for aortic disease. It is for people with moderate kidney problems who are having planned surgery that stops the heart briefly.
This study compares two medications given during surgery to see which one better protects the kidneys after the procedure. If you are having major non-cardiac surgery that lasts at least 2 hours and you need medication to support your blood pressure, this trial may be a good fit.
This trial tests whether giving a medicine called angiotensin II during heart surgery can help prevent acute kidney injury (a sudden drop in kidney function). It is for adults having certain types of heart surgery who have a higher risk of kidney problems.
Hear when a new Cardiac Surgical Procedures trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.