Fruquintinib, serplulimab, and chemotherapy for advanced colorectal cancer
Part of Cancer, Digestive system clinical trials.
This study tests a combination of three drugs—fruquintinib (an anti-angiogenic agent), serplulimab (an immune-boosting antibody), and standard chemotherapy—as a first-line treatment for advanced colorectal cancer with specific genetic mutations. The goal is to see if this combination can help shrink or control tumors better than standard treatment alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–75 years old
- Advanced colorectal cancer that cannot be surgically removed or has spread to other parts of the body
- Genetic testing confirms RAS or BRAF mutation in your cancer
- No prior chemotherapy for advanced cancer (though prior treatment for early-stage disease is allowed if recurrence occurred 6+ months later)
- Good overall health status and adequate organ/blood cell function (checked by blood tests)
- If female and able to have children: negative pregnancy test and agreement to use contraception during and 6 months after treatment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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