Testing daidzein supplement effects on fatty liver before surgery
Part of Digestive system, Hormones & metabolism clinical trials.
This study tests whether taking daidzein (a plant compound) for a few weeks before gallbladder surgery can improve fatty liver disease. You'll have blood tests and a small liver tissue sample taken during surgery to see if the supplement helps.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–70 and scheduled for elective gallbladder or biliary surgery for benign (non-cancerous) disease
- Diagnosed with metabolic dysfunction-associated steatotic liver disease (fatty liver with at least one cardiometabolic risk factor like high blood pressure, diabetes, or high cholesterol)
- At least 28 days between enrollment and your planned surgery
- Willing to avoid all soy-containing foods (tofu, soy milk, miso, edamame, tempeh, etc.) during the study
- Able to provide blood, urine, and intraoperative liver tissue samples and sign informed consent
- No viral hepatitis, autoimmune liver disease, cirrhosis, significant alcohol use (>140g/week for women, >210g/week for men), or recent antibiotics/probiotics
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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