Botulinum Toxin for Piriformis Muscle Syndrome Pain
Treatments studied
Part of Brain & nervous system, Pain clinical trials.
This study tests whether botulinum toxin (Botox) injected into the piriformis muscle—a muscle deep in the buttock that can pinch the sciatic nerve—reduces pain and improves quality of life. You qualify if you have one-sided buttock and leg pain that hasn't improved with physical therapy or pain medication.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Diagnosed with piriformis syndrome (buttock/leg pain from a pinched nerve) on one side for at least 3 months
- Pain rated at least 4 out of 10 on a pain scale
- Have tried physical therapy, muscle relaxants, or pain medication without enough relief
- MRI or CT scan showing no herniated disc or severe scarring of the piriformis muscle
- No history of botulinum toxin injections or piriformis muscle surgery
- Health insurance coverage and ability to keep a daily symptom diary
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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