Testing a new collagenase injection for Dupuytren's contracture
Part of Bones, joints & muscles, Cancer, Skin clinical trials.
This study tests whether a new injectable enzyme called CNT201 can safely and effectively treat Dupuytren's contracture—a condition where fingers curl and can't straighten. The injection aims to break down the thick tissue cords causing the problem, without surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–75 years old
- Diagnosed with Dupuytren's contracture (curled finger(s) with at least 20° of stiffness, but not more than 100° in finger knuckles or 80° in middle joints)
- Unable to flatten your affected finger(s) and palm on a table at the same time (positive Table Top Test)
- Never received collagenase treatment (Xiaflex or Xiapex) before for Dupuytren's
- No prior hand surgery, needle treatment, or other injections for Dupuytren's in the past 90 days
- Overall good health with no chronic hand, nerve, or muscle disorders
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a minimally invasive procedure that uses a needle to release tight tissue in the hand, and may include a steroid injection. It aims to improve hand finger straightening for people with Dupuytren’s contracture.
This trial looks at whether a minimally invasive needle procedure can improve hand stiffness caused by Dupuytren’s disease. It may help reduce finger bending that affects how you use your hand.
This trial tests a less invasive procedure using a needle-knife guided by ultrasound to treat Dupuytren's contracture, which causes fingers to curl. It may be an option if you haven't had prior treatment on the same hand and are in otherwise good health.
This study tests if a short course of radiation therapy can help prevent Dupuytren's contracture from coming back after a non-surgical release (like an injection). It may be an option for people whose finger is already bent and cannot touch the table.
This study looks at whether doing a limited surgery in advance can improve outcomes and reduce scarring for people with trigger finger who also have a specific palm cord condition. It may help you heal better if you’ve already tried non-surgical treatment or chose surgery.
This trial looks at using radiation after contracture-release surgery for people with Dupuytren’s disease. It may help prevent the hand tightening from coming back and improve hand function.
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