Clin2
NCT07641010Possibly a fitNot yet recruiting

Combination treatment for newly diagnosed pediatric Hodgkin lymphoma

Hodgkin Lymphoma

Treatments studied

Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.

This trial tests a new combination of two drugs—a PD-1 antibody and a JAK1 inhibitor—for children and teens with newly diagnosed Hodgkin lymphoma. The goal is to see if this combination can help treat the cancer more effectively.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
112 people
Ages
6 years to 18 years
Study type
Interventional

Who can take part

  • You are between 6 and 18 years old.
  • You have been diagnosed with classic Hodgkin lymphoma and have not yet received treatment for it.
  • You have at least one measurable tumor that can be seen on a scan.
  • You are generally able to perform daily activities (ECOG 0-2).
  • Your blood counts and organ function meet certain levels.
  • You do not have other serious health conditions like active infections or severe heart problems.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07551583Recruiting· Phase 2
Nivolumab plus chemotherapy for early-stage Hodgkin lymphoma in young people

This study tests a combination of a newer immunotherapy drug (nivolumab) with standard chemotherapy (AVD) in children, teens, and young adults with newly diagnosed, early-stage Hodgkin lymphoma—a blood cancer affecting lymph nodes. The goal is to see if adding immunotherapy improves outcomes while being tolerable for this age group.

Houston, Texas
NCT03618550Recruiting· Phase 2
Pembrolizumab plus chemotherapy for relapsed Hodgkin lymphoma

This study tests a combination of the immunotherapy drug pembrolizumab with a chemotherapy regimen called GVD for patients whose Hodgkin's lymphoma has not responded or has returned after initial treatment. The goal is to see if this combination works better than standard approaches.

Duarte, California
NCT05627115Not yet recruiting· Phase 2
Immunotherapy plus chemotherapy for older adults with hodgkin lymphoma

This trial tests a drug called tislelizumab (an immunotherapy that helps your immune system fight cancer) added to standard chemotherapy for older adults with newly diagnosed Hodgkin lymphoma. The goal is to see if adding this drug improves outcomes without too many side effects.

NCT06812858Recruiting· Phase 2
PD-1 inhibitor maintenance after stem cell transplant for Hodgkin lymphoma

This trial tests whether a PD-1 inhibitor (a type of immunotherapy) given after an autologous stem cell transplant can help prevent Hodgkin lymphoma from coming back in people at high risk of relapse.

Astana
NCT05253495Recruiting· Phase 2
Targeted immunotherapy added to chemotherapy and radiation for lymphoma

This Phase 2 trial tests whether adding targeted immunotherapy to standard chemotherapy and radiation can improve outcomes in children with certain types of lymphoma. It may help the immune system work better against cancer.

Birmingham, Alabama
NCT06090864Recruiting· Phase 1/Phase 2
Engineered immune cells for Hodgkin lymphoma

This trial tests a new treatment where your own immune cells are modified to better attack Hodgkin lymphoma cells. It is for people whose disease has not responded to other therapies.

Chapel Hill, North Carolina

Hear when a new Hodgkin Lymphoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.