Nivolumab plus chemotherapy for early-stage Hodgkin lymphoma in young people
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This study tests a combination of a newer immunotherapy drug (nivolumab) with standard chemotherapy (AVD) in children, teens, and young adults with newly diagnosed, early-stage Hodgkin lymphoma—a blood cancer affecting lymph nodes. The goal is to see if adding immunotherapy improves outcomes while being tolerable for this age group.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 2 to 21 years old
- Newly diagnosed early-stage Hodgkin lymphoma (stage I or II) with small tumors (under 10 cm)
- Never received chemotherapy or immunotherapy for lymphoma before (steroids alone are okay)
- Heart pumping function is normal or near-normal (ejection fraction over 40%)
- Liver and kidney function tests are acceptable or any problems are from the lymphoma itself
- Able to handle the physical demands of treatment (good overall health status)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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