WT1-targeting T cells with azacitidine for AML
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new type of cell therapy for people with acute myeloid leukemia (AML) that has minimal residual disease (small amounts of cancer left after treatment). The therapy uses your own immune cells, modified to target a protein called WT1 on leukemia cells, and combines it with a drug called azacitidine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with AML, but not the M3 subtype (acute promyelocytic leukemia).
- You have a specific genetic marker (HLA-A*02:01) that makes this therapy suitable for you.
- Your leukemia cells show the WT1 protein.
- You have minimal residual disease (MRD) after initial treatment, meaning small amounts of leukemia are still detectable but you are in remission.
- You are overall healthy enough for treatment, with adequate heart, liver, and kidney function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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