Clin2
NCT07645690Possibly a fitRecruiting

CD70 CAR-T Cell Therapy for Advanced Kidney Cancer

Unresectable or Metastatic Clear Cell Renal Cell Carcinoma

Part of Cancer, Kidney & urinary clinical trials.

This early-stage trial tests a new type of cell therapy called CD70 CAR-T for advanced kidney cancer (clear cell renal cell carcinoma) that has spread or cannot be surgically removed. The therapy uses cells from your own immune system that are genetically modified to recognize and attack cancer cells.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Enrollment
30 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • Age 18–75 years old
  • Diagnosed with advanced or unresectable clear cell kidney cancer that has grown or spread after at least two prior treatments (including immunotherapy and a targeted drug)
  • Your tumor tissue must show CD70 protein expression (a marker the CAR-T cells target)
  • At least one measurable tumor visible on imaging
  • Good overall health status (Karnofsky Performance Status score ≥70%, meaning you can manage most daily activities)
  • Normal or near-normal blood counts, liver, kidney, heart, and lung function

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05947487Recruiting· Phase 1/Phase 2
CAR-T treatment for CD70-positive advanced solid tumors

This Phase 1/2 trial tests a lab-made immune therapy (CAR-T) designed to attack cancers that have a protein called CD70. It may help people whose solid tumor has not responded to standard treatment, but it also requires specific lab confirmation and careful health screening.

Beijing, Iotherapeutic Department of Chinsese PLA Gereral Hospital
NCT06728189Recruiting· Phase 1
CD70-targeted CAR-NKT cells for advanced solid tumors

This trial tests a new type of immune cell therapy (CAR-NKT cells) that targets a protein called CD70 on cancer cells. It is for people with advanced solid tumors that have not responded to at least two prior treatments.

Beijing
NCT05948033Recruiting· Phase 1/Phase 2
CD70-targeted CAR-T for relapsed lymphoma with CD70

This trial studies a type of immune therapy called CD70-targeted CAR-T for people whose lymphoma has come back or did not respond after standard treatments. It may help by training your own T cells to recognize and attack lymphoma cells that carry the CD70 marker.

Beijing, Biotherapeutic Department of Chinsese PLA Gereral Hospital
NCT07647744Recruiting· Phase 1
CD70-Targeted Cell Therapy for Advanced Kidney Cancer

This study tests a new cell-based treatment designed to target kidney cancer cells that have a protein called CD70. The treatment involves collecting your immune cells, modifying them in the lab, and infusing them back to fight the cancer. It's for patients with advanced kidney cancer who have already tried at least one standard immunotherapy.

Shanghai
NCT07113977Not yet recruiting· Early Phase 1
Modified immune cells for advanced kidney cancer

This trial is testing a new type of cell therapy for advanced kidney cancer that has not responded to standard treatments. The therapy takes your own immune cells, modifies them to target a protein called CD70 on the cancer cells, and gives them back to you to help fight the cancer.

NCT07072234Recruiting· Phase 1
CAR NK cell therapy for advanced clear cell kidney cancer

This trial tests a new type of immune cell therapy (CAR NK cells) that targets a protein called CD70 on kidney cancer cells. It's for people with advanced clear cell kidney cancer that hasn't responded to standard treatments.

Houston, Texas

Hear when a new Unresectable or Metastatic Clear Cell Renal Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.