Safety trial of modified yeast to prevent C. difficile infection
Part of Infections clinical trials.
This study tests whether a specially engineered yeast (taken as a pill) can safely help prevent Clostridioides difficile infection—a serious gut infection that can develop after antibiotics. Part A enrolls healthy volunteers; Part B enrolls people at higher risk (those with prior C. difficile, recent hospitalization, or recent antibiotics).
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–75 and able to swallow pills and attend all study visits over 5+ weeks
- Willing to take the study yeast pill daily for 28 days and provide blood and stool samples
- Generally healthy with stable medical conditions for at least 1–3 months (Part A stricter than Part B)
- No pregnancy or breastfeeding; if you can get pregnant, you must use reliable birth control for 6+ weeks total
- Avoid all probiotics, yogurt, kefir, kombucha, and fermented foods from one week before the study through day 36
- No daily heartburn, bowel, or acid-reducing medications for 1–3 months before enrollment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies using a fecal microbiota transplant (FMT)—healthy gut bacteria moved from a screened donor—to help treat recurring or hard-to-control C. difficile infection. It may help restore a healthier gut environment when standard treatments keep failing or the infection returns.
This trial tests whether giving vancomycin through a tube into the stomach can prevent a serious gut infection called C. diff in people who are very sick in the ICU and taking antibiotics. If you qualify, you might receive this medicine to lower your risk.
This study tests a new antibody (AZD5148) to prevent C. diff infection from coming back. If you have a current C. diff infection and are being treated with antibiotics, you may be able to join.
This trial studies how Clostridioides difficile (C. diff) affects healthy people by intentionally giving a controlled dose. The goal is to understand the infection better and help develop future treatments or vaccines.
This trial tests whether giving a stool transplant (also called FMT) can treat a new, early C. difficile infection in people who have improved while on antibiotics. It may help some people prevent the infection from coming back or worsening.
This trial tests a new treatment called CMTS0929 for people with C. diff infection. It aims to see if the treatment can help clear the infection and improve symptoms.
Hear when a new Clostridium Difficile Infection trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.