Preventing C. diff return with an antibody
Part of Infections clinical trials.
This study tests a new antibody (AZD5148) to prevent C. diff infection from coming back. If you have a current C. diff infection and are being treated with antibiotics, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have or be recovering from a C. diff infection with diarrhea (at least 3 loose stools in 24 hours for 2 days) and a positive stool test.
- You must be starting or already taking an antibiotic for this C. diff infection, with a planned treatment of 10 to 28 days.
- You must weigh at least 77 pounds (35 kg).
- You should not have had a fecal transplant or be planning one within the next 6 months, and you should not have had the C. diff antibody bezlotoxumab in the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether adding a bile acid supplement (ursodeoxycholic acid) to standard antibiotics can help prevent a repeat C. diff infection. It is for people who have already had a C. diff infection and have at least one factor that increases their risk of it coming back.
This study tests a new live bacteria product (EXL01) given with vancomycin to prevent C. diff from coming back. It is for people who have already had C. diff two or more times and are at high risk of another infection.
This trial tests whether taking vancomycin by mouth can prevent another C. diff infection when you need to take other antibiotics. It’s for patients who recently had C. diff and are about to start a new antibiotic course.
This study tests whether specific lifestyle changes during treatment for C. difficile infection (a serious gut bacteria infection) can help prevent it from coming back. You'll receive standard antibiotic treatment and follow a controlled diet while researchers track your recovery.
This trial tests a new medicine called VE303, a live bacterial therapy, to prevent C. diff infections from coming back. It is for people who have had C. diff at least once in the last 6 months, or who are at high risk for a repeat infection due to age or other health problems.
This trial tests a new treatment called CMTS0929 for people with C. diff infection. It aims to see if the treatment can help clear the infection and improve symptoms.
Hear when a new Clostridioides Difficile Infection trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.