Experimental treatment for C. difficile infection
Part of Infections clinical trials.
This trial tests an experimental treatment called CMTS0929 for people with a C. difficile infection that is causing diarrhea. The treatment is given through a tube placed through the nostril or mouth into the intestine, and the study will see if it is safe and helpful.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must have a confirmed diagnosis of C. difficile infection (a lab test positive for the bacteria or its toxins).
- You must currently have diarrhea (at least 3 loose or watery stools per day for 2 or more days).
- You must not have a weakened immune system (for example, from HIV, low blood cell counts, or taking immune-suppressing drugs or high-dose steroids).
- You must not have other active infections besides C. difficile.
- You must not have had major abdominal surgery (like bowel resection) in the last 6 months, and must be able to undergo a procedure through the anus into the bowel.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a treatment called washed microbiota transplantation (WMT) for people with a C. diff infection that causes diarrhea. WMT uses processed donor bacteria to help restore healthy gut balance and fight the infection.
This trial tests whether giving a stool transplant (also called FMT) can treat a new, early C. difficile infection in people who have improved while on antibiotics. It may help some people prevent the infection from coming back or worsening.
This trial compares three treatments for a severe diarrhea infection called C. diff: a fecal transplant (putting healthy donor stool into your gut), a newer antibiotic called fidaxomicin, and an older antibiotic called vancomycin. The goal is to see which works best and prevents the infection from coming back.
This study tests a freeze-dried fecal microbiota transplant (FMT) to see if it helps with diarrhea-predominant irritable bowel syndrome (IBS-D) or prevents repeat C. diff infections. FMT introduces healthy bacteria into your gut to restore balance.
This study tests whether the supplement alanyl-glutamine, given along with standard treatment, can improve outcomes for adults being treated for C. difficile infection (a cause of diarrhea). It may help the body recover better after antibiotics that usually treat C. difficile.
This study is tracking patients with a confirmed C. difficile infection to understand how the body responds and how treatments work. You may be asked to do follow-up visits for up to 5 years.
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