Finding family members at risk for familial high cholesterol
Part of Genetic & congenital, Hormones & metabolism clinical trials.
This study uses a 'cascade testing' approach, where family members of people with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol, are tested to see if they also have it. The goal is to identify and test at-risk relatives early so they can get treatment to prevent heart problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have a confirmed diagnosis of familial hypercholesterolemia (FH) or a genetic test confirming it.
- You are part of a Mayo Clinic program (like the REP or Tapestry database) that identified you.
- You have at least one first- or second-degree relative (like a parent, sibling, child, grandparent, aunt, uncle, niece, nephew, or grandchild) who could be tested.
- You can use email regularly.
- You have not already taken part in a similar structured family testing program before.
- If you are a relative, you are 1 year or older and are related to someone with FH in the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is about helping families with familial hypercholesterolemia (a genetic condition that causes very high cholesterol) get screened. It tests a way to reach close relatives so they can learn their risk and consider next steps.
This study aims to find and help people with very high cholesterol, which can run in families. If you or your child have high cholesterol, this study may help you understand your risk and get the right care.
This trial focuses on people with familial hypercholesterolemia (FH), an inherited condition that causes very high cholesterol. It aims to better understand and manage severe cholesterol problems that raise heart risk, especially in families.
This registry collects information from people with inherited high cholesterol to better understand the condition and care needs. You may be invited to share blood and medical test results, especially your cholesterol and related health history.
This trial is a global registry that collects health and genetic information from people with familial hypercholesterolemia (FH) and sometimes from their relatives. The goal is to better understand FH and how it presents, which can help improve care for families affected by high cholesterol.
This trial focuses on people referred to a cholesterol (lipid) clinic to help identify inherited high cholesterol. It tests an “interpretive comment” approach to nudge detection—meaning it may help clinicians recognize who is most likely to have familial hypercholesterolemia.
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