Registry for inherited high cholesterol (familial hypercholesterolemia)
Part of Genetic & congenital, Heart & circulation, Hormones & metabolism clinical trials.
This registry collects information from people with inherited high cholesterol to better understand the condition and care needs. You may be invited to share blood and medical test results, especially your cholesterol and related health history.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your untreated (before treatment) total cholesterol is very high, or your untreated LDL (“bad cholesterol”) is very high
- You have familial hypercholesterolemia, either confirmed by a known gene change or a clinical diagnosis
- You have genetic confirmation such as a mutation in LDL receptor, ApoB, or PCSK9 (or meet accepted FH diagnosis criteria)
- Your thyroid issue is not poorly controlled at screening
- Your kidneys are functioning well enough at screening (no serious kidney dysfunction or nephrotic syndrome)
- Your diabetes is not poorly controlled at screening
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is a global registry that collects health and genetic information from people with familial hypercholesterolemia (FH) and sometimes from their relatives. The goal is to better understand FH and how it presents, which can help improve care for families affected by high cholesterol.
This trial focuses on people with familial hypercholesterolemia (FH), an inherited condition that causes very high cholesterol. It aims to better understand and manage severe cholesterol problems that raise heart risk, especially in families.
This trial focuses on people referred to a cholesterol (lipid) clinic to help identify inherited high cholesterol. It tests an “interpretive comment” approach to nudge detection—meaning it may help clinicians recognize who is most likely to have familial hypercholesterolemia.
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This study aims to find and help people with very high cholesterol, which can run in families. If you or your child have high cholesterol, this study may help you understand your risk and get the right care.
This study looks at children who may have inherited high cholesterol, especially when one parent is affected. It may help doctors detect the condition earlier and understand how it runs in families.
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