Clin2
NCT07665450Possibly a fitRecruiting

Ramantamig plus daratumumab for untreated multiple myeloma without stem cell transplant

Multiple Myeloma

Treatments studied

Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.

This trial tests a new combination of two drugs, ramantamig and daratumumab, against other standard treatments for people newly diagnosed with multiple myeloma who are not planning to have a stem cell transplant. The goal is to see if this combination works better at controlling the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
1,000 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have been diagnosed with multiple myeloma.
  • You are not planning to have a stem cell transplant, either because of age or other health conditions.
  • Your daily activity level is mostly normal (you can care for yourself, though you may need some help).
  • You have not had treatment for multiple myeloma before, except possibly a short course of steroids in an emergency.
  • You are not considered frail, unless frailty is only due to age.
  • You do not have any known allergies to the study drugs or their ingredients.
  • You have not had major surgery or serious injury in the past 2 weeks, and you do not have any planned during the trial.
  • You do not have multiple myeloma that has spread to your brain or spinal cord.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07830485Not yet recruiting· Phase 2
Combination therapy for newly diagnosed multiple myeloma without stem cell transplant

This trial tests a combination of three drugs (CM336, daratumumab, and lenalidomide) for people with newly diagnosed multiple myeloma who are not eligible for a stem cell transplant. The goal is to see if this combination is safe and effective in controlling the disease.

Tianjin, Tianjin Municipality
NCT06679101Recruiting· Phase 3
Belantamab combination vs standard care for newly diagnosed multiple myeloma

This trial tests a new drug combination (belantamab mafodotin plus lenalidomide and dexamethasone) against the usual treatment for people newly diagnosed with multiple myeloma who cannot have a stem cell transplant. It aims to see if the new combination works better.

Mobile, Alabama
NCT07671287Not yet recruiting· Phase 3
New drug combination for untreated multiple myeloma

This trial is testing a new combination of drugs for people with untreated multiple myeloma who are healthy enough for a stem cell transplant. It aims to see if the treatment is safe and effective.

NCT05623020Recruiting· Phase 3
New treatment for newly diagnosed transplant-ineligible myeloma

This Phase 3 study compares a three-drug combination (elranatamab, daratumumab, and lenalidomide) versus a standard three-drug treatment (daratumumab, bortezomib, lenalidomide, plus dexamethasone). It aims to see which plan works better for people newly diagnosed with multiple myeloma who cannot get a stem cell transplant.

Jupiter, Florida
NCT07247097Not yet recruiting· Phase 2
Comparing two drug combinations for newly diagnosed multiple myeloma

This trial tests two different drug combinations for people newly diagnosed with multiple myeloma who are not getting a stem cell transplant right away. It compares one drug (elranatamab) to another (daratumumab), both given with a standard three-drug regimen called RVd Lite, to see which works better.

Boston, Massachusetts
NCT05020236Recruiting· Phase 3
Elranatamab with daratumumab for previously treated myeloma

This trial studies elranatamab (alone and combined with daratumumab) in people with multiple myeloma who have already received other treatments, including lenalidomide. It aims to see how well these medicines control the cancer and what side effects people experience.

Clovis, California

Hear when a new Multiple myeloma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.