Infliximab eye drops for severe dry eye from Sjögren's syndrome
Part of Bones, joints & muscles, Eyes & vision, Immune system & allergy, Mouth & dental, Skin clinical trials.
This study tests whether an eye drop containing infliximab (a drug that blocks inflammation) can safely reduce severe dry eye symptoms caused by Sjögren's syndrome, and it also looks at how well the drug works.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have a confirmed diagnosis of Sjögren's syndrome (a condition that causes dry eyes and mouth).
- Your dry eye symptoms must be severe, with a doctor-confirmed score of at least 6 on an eye staining test and a symptom score of at least 33 on the OSDI questionnaire.
- You must be on a stable dose of non-biologic immunosuppressive medications (like methotrexate or hydroxychloroquine) for at least 12 weeks before starting the study.
- You must not have used certain eye drops (like steroids, cyclosporine) in the last 30 days, or punctal plugs in the last 3 months.
- You must not have a history of tuberculosis, active infections, or certain other conditions that would make infliximab unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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