Preventing GVHD after stem cell transplant with three drugs
Part of Immune system & allergy clinical trials.
This trial tests a combination of three drugs (PTCy, bortezomib, and sitagliptin) after a stem cell transplant to help prevent graft-versus-host disease (GVHD). It is for people with certain blood cancers who are getting a reduced-intensity (gentler) transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a blood cancer like AML, ALL, MDS, CMML, or therapy-related MDS.
- You are 18 years or older.
- You have a matched stem cell donor (a sibling or unrelated donor from the registry).
- You are able to receive a reduced-intensity (gentler) conditioning regimen.
- You have good kidney, liver, and lung function.
- You are not pregnant, nursing, or planning to become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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