Testing metformin for recurrent appendix cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests whether the drug metformin (a common diabetes pill) can help control pseudomyxoma peritonei, a rare abdominal cancer. It is for people whose cancer has come back or cannot be surgically removed, and who aren't planning a major surgery with heated chemotherapy at this time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have pseudomyxoma peritonei (a rare abdominal cancer that causes mucus buildup) that started from your appendix.
- Your disease has come back after treatment, cannot be surgically removed, or you are not planning major surgery with heated chemotherapy right now.
- You are 18 years of age or older.
- You are healthy enough to be up and about for at least half the day (ECOG score 0, 1, or 2).
- You are not currently taking metformin for diabetes or another condition.
- You have never had a bad reaction to metformin in the past.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a chemotherapy combination (capecitabine and cyclophosphamide) given before surgery for people with a large amount of pseudomyxoma peritonei (PMP). The goal is to see if it can shrink the tumor and make surgery more effective.
This trial compares two different schedules of heated chemotherapy (HIPEC) after surgery for pseudomyxoma peritonei (a rare appendix cancer that spreads in the abdomen). It may help determine whether one or three cycles of HIPEC is better for controlling the disease.
This trial tests if an intestinal or multi-organ transplant can help people with a rare, widespread abdominal cancer called pseudomyxoma peritonei that cannot be removed by standard surgery. The goal is to remove all visible cancer and replace affected organs with a donated transplant.
This trial tests a vaccine for people with a rare abdominal cancer called pseudomyxoma peritonei (PMP) that has come back or cannot be removed by surgery. The vaccine is designed to help the immune system fight the cancer. It is for people whose tumor has a specific genetic change (GNAS mutation) and who have no other standard treatment options.
This trial compares a lower dose of heated chemotherapy (HIPEC) given during surgery to a standard dose for patients with pseudomyxoma peritonei (a condition where jelly-like mucus builds up in the abdomen). The goal is to see if the lower dose works just as well with fewer side effects.
This study tests if metformin, a common diabetes medicine, can help reduce insulin resistance in women who finished chemotherapy for early-stage breast cancer. It aims to improve long-term health and prevent future problems.
Hear when a new Pseudomyxoma Peritonei trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.