How weight-loss medications affect body muscle, with and without exercise
Part of Hormones & metabolism clinical trials.
This study looks at what happens to your body (especially muscle) when you take a newer weight-loss medication, either with or without adding an exercise program. It could help you understand how to best protect your muscle while losing weight.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 64 years old and have been prescribed a new weight-loss medication (like semaglutide or tirzepatide) that you'll start soon.
- Your BMI is 30 or higher, or your BMI is 27-29.9 with a related health problem (e.g., high blood pressure, sleep apnea).
- You do not have type 2 diabetes.
- You have been doing little to no regular exercise (less than 60 minutes per week) over the past 3 months.
- You have not had weight-loss surgery in the past, and are not currently pregnant or planning pregnancy.
- You do not have heart problems, uncontrolled high blood pressure, or conditions that make MRI or weight loss unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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